Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
As the director of Notre Dame’s W.M. Keck Center for Transgene Research, Frank Castellino studies the processes by which human bodies form and dissolve blood clots. Among a number of important breakthroughs, he has established the mechanism of plasminogen activation, a key function related to the body’s formation of a clot-dissolving enzyme. This and other lines of his research have direct and potentially transformative applications for a variety of human health problems, including heart disease, stroke, cancer, and hemophilia.
Castellino was a principal investigator on a recently completed Program Project Grant from the National Institutes of Health—a rare distinction for a faculty member at a university without a medical school. The grant supported his efforts to examine the relationship between hemostasis, inflammation, and sepsis.
The editor-in-chief of Current Drug Targets, Castellino is an elected fellow of the American Association for the Advancement of Science, the New York Academy of Sciences, and the American Heart Association.
Established in 1976, this professorship is named for donors Dr. Ervin C. Kleiderer and Dr. Margaret Pezold Kleiderer. Ervin, a distinguished Indianapolis research chemist, was the executive director of research, development, and control at Eli Lilly and Co. Both Ervin and Margaret were active on Notre Dame’s advisory councils.